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| | | |
Prilocaine Dose, mg
|
|---|
| | | |
30
|
35
|
40
|
45
|
50
|
55
|
|---|
| | | |
Working model
|
|---|
| | | |
0.5
|
0.75
|
0.90
|
0.95
|
0.98
|
0.99
|
|---|
|
Cohort
|
Administered dose, mg
|
Clinical response
|
Updated Estimated Probability of Response
|
|---|
|
1
|
45
|
S,S,S,S
|
0.66
|
0.89
|
0.97
|
0.99
|
1.00
|
1.00
|
|
2
|
40
|
S,S,S,S
|
0.73
|
0.93
|
0.99
|
0.99
|
1.00
|
1.00
|
|
3
|
40
|
S,S,S,S
|
0.76
|
0.94
|
0.99
|
1.00
|
1.00
|
1.00
|
|
4
|
35
|
F,F,S,F
|
0.48
|
0.73
|
0.88
|
0.93
|
0.97
|
0.99
|
|
5
|
50
|
S,S,S,S
|
0.49
|
0.74
|
0.89
|
0.95
|
0.98
|
0.99
|
|
6
|
45
|
S,S,S,S
|
0.51
|
0.76
|
0.91
|
0.95
|
0.98
|
0.99
|
|
7
|
45
|
S,S,S,S
|
0.53
|
0.78
|
0.92
|
0.96
|
0.99
|
1.00
|
|
8
|
45
|
S,S,S,S
|
0.54
|
0.79
|
0.93
|
0.97
|
0.99
|
0.99
|
|
9
|
40
|
S,S,S,F
|
0.50
|
0.75
|
0.90
|
0.95
|
0.98
|
0.99
|
|
10
|
45
|
S,S,S,F
|
0.46
|
0.71
|
0.87
|
0.9322
|
0.9702
|
0.99
|
- In bold is the estimated posterior probability of the dose level considered to be the currently best estimate of the ED95 after the inclusion of the cohort
- F = Failure, S = Success
