Table 6 Effect of covariate analysis on variance ( ω 2 ) of V2
From: Covariates of intravenous paracetamol pharmacokinetics in adults
| Sequential Nested Model | PPVt2 | BSVR2 | BOV2 | PPVP2 | PPVP2/PPVt2 |
|---|---|---|---|---|---|
| No covariates | 0.437 | 0.437 | 0 | 0 | 0 |
| Allometric scaling (TBW) | 0.437* | 0.396 | 0.00297 | 0.03803 | 0.087025 |
| Allometric scaling (NFM) | 0.437* | 0.348 | 0.00325 | 0.08575 | 0.196224 |
| F AGEV2 | 0.437* | 0.304 | 0.00272 | 0.13028 | 0.298124 |
| F ICV2 | 0.437* | 0.299 | 0.00222 | 0.13578 | 0.310709 |
| F ORTHOV2 | 0.437* | 0.246 | 0.0258 | 0.1652 | 0.378032 |