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Table 5 Effect of covariate analysis on variance ( ω 2 ) of Clearance

From: Covariates of intravenous paracetamol pharmacokinetics in adults

Sequential nested model PPVt2 BSVR2 BOV2 PPVP2 PPVP2/PPVt2
No covariates 0.19 0.19 0 0 0
Allometric scaling (TBW) 0.19* 0.10 0.0413 0.0487 0.256
Allometric scaling (NFM) 0.19* 0.0889 0.0557 0.0454 0.239
F AGECL 0.19* 0.0799 0.0557 0.0544 0.286
F PREGCL 0.19* 0.0803 0.0513 0.0584 0.3074
F ABDCL 0.19* 0.0605 0.0533 0.0762 0.401
  1. * = assumed from no covariate model estimate.
  2. [PPV = population parameter variability; BSV = between subject variability; BOV = between occasion variability; TBW = total body weight; NFM = normal fat mass; preg = pregnant, abd = abdominal surgery; IC = intensive care patients; ortho = orthopaedic surgery].
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BMC Anesthesiology

ISSN: 1471-2253

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